Roanoke Church of Christ is involved in a few ministries:
- Ezell Clinic – Located in Guatemala, Ezell Clinic is a Medical Mission supported each month by the congregation. Each year the church sends a volunteer to work at the clinic for a week.
- ABC – ABC is also located in Guatemala, educates the children in the area served by the Clinic.
- Bread for a Hungry World – On each third Sunday, a special contribution is taken to help feed the hungry of the world. These funds are sent to, and distributed by, the Richard Hills Church of Christ in Fort Worth, Texas.